Maurice Manning, Ph.D., D.Sc.
Department of听Cell and Cancer Biology
Ombudsman, The University of Toledo College of Medicine听and Life Sciences
maurice.manning@utoledo.edu
Curriculum Vitae听
List of Scientists Who Have Received Peptides as Research Tools 1980-2023
EDUCATION:
| B.Sc. | 1957 | Chemistry | University College of Galway*, Galway, Ireland |
| M.Sc. | 1958 | Chemistry | University College of Galway*, Galway, Ireland |
| Ph.D. | 1961 | Organic Chemistry | University of London, London, England |
| D.Sc. | 1974 | Peptide Chemistry | University College of Galway*, Galway, Ireland |
*Now The National University of Ireland, Galway (NUIG)
RESEARCH INTERESTS:
Research in my laboratory听focused on the design and solid phase synthesis of peptide
ligands for the vasopressin V1a, V1b and V2 receptors and for the oxytocin (OT) receptor听(selective agonists and听antagonists;
radioiodinated and fluorescent ligands).听 Many of these peptides have been utilized
as research tools in laboratories worldwide and have helped to advance research in
the oxytocin vasopressin field. To date, over 3,000 samples of oxytocin and vasopressin
agonists and antagonists from this laboratory have been donated to over 740 scientific
investigators (some multiple times) for their own independent studies (see听list above). Over 2,000 publications from other laboratories have resulted from the use of these
peptides over the past 30 years.听听I听continue to supply other scientists in the U.S.
and throughout the world with samples of vasopressin and oxytocin peptide agonists,听antagonists
and radioiodinateable ligands for their own independent studies.
Currently these peptide designs are focused on the CNS actions of oxytocin and vasopressin;
with the following goals in mind:听 (1) the design of (a) long-acting oxytocin agonists,
(b) fluorescent oxytocin agonists, and (c) "biased" oxytocin agonists;听for use as
pharmacological tools and as potential therapeutic agents for the study of and treatment
of autism spectrum disorders (ASD) and related disorders and (2) the design of selective
antagonists, radiolabelled and fluorescent ligands for the human and rat vasopressin
V1b receptors;听for studies on V1b receptors in the brain听and as potential new therapies for anxiety and stress.听 The
synthetic studies have been carried out in my laboratory by returning visiting scholars
from Poland:听 Drs. Krzysztof Bankowski, Aleksandra Olma and Aleksandra Misicka, and
Bulgaria: Dr. Stoytcho Stoev.听 All have made听important contributions to my laboratory
in the past.听 The resultant peptides, are being听pharmacologically characterized by
long time collaborators Drs. Gilles Guillon, Maithe Corbani, Thierry Durroux and Bernard
Mouillac, Montpellier, France;听and by Drs. Bice Chini and Marta Busnelli, Milan, Italy.
REPRESENTATIVE PUBLICATIONS:
S. Derick, L.L. Cheng, M.J. Voirol, S. Stoev, M. Giacomini, N.C. Wo, H.H. Szeto, M.
Ben Mimoun, M. Andres, R.C. Gaillard, G. Guillon and M. Manning (2002) Endocrinology 143:4655-4664.
A. Pena, B. Murat, M. Trueba, M.A. Ventura, G.听Bertrand, L.L. Cheng, S. Stoev, H.H.
Szeto, N. Wo, G. Brossard, C. Serradeil-Le Gal, M. Manning and G. Guillon (2007) .听听Endocrinology 148:4136-4146.
M. Manning听(2008) Impact of the Merrifield Solid Phase Biopolymers (Peptide Science)听90(3):203-212.
B. Chini and M. Manning (2007) 听 Biochem. Soc. Transactions 35 (Pt4):737-741.
M. Manning, S. Stoev, B. Chini, T. Durroux, B. Mouillac and G. Guillon (2008)听.听 In Advances in Vasopressin and Oxytocin -听from Genes to Behaviour and Disease (eds.
Rainer Landgraf and Inga Neumann) Prog. Brain Res.听170:473-512.
M. Manning.听 .听 Invited commentary in The European Peptide Society Newsletter (Ed. Paul Cordopatis).听听European
Peptide Society:听 Issue Number 41: 14, January 2010.听听Reprinted in American Peptide
Society Newsletter, Spring 2010, page 5.
L. Albizu, M. Cottet, M. Kralikova, S. Stoev, R. Seyer, I. Brabet, T. Roux, H. Bazin,
E. Bourrier, L. Lamarque, C. Breton, M.-L. Rives, A.H. Newman, J.A. Javitch, E. Trinquet,
M. Manning, J.-P. Pin, B. Mouillac and T. Durroux (2010)听听 Nature Chem. Biol.听6:587-594.
B. Mouillac, M. Manning and T. Durroux. (2008)听.听听Mini Reviews in Medicinal Chemistry 8(10):996-1005.
M. Manning, S. Stoev and K. Bankowski.听 . Proceedings of the 31st European Peptide Symposium (M. Lebl, M. Mendal, K.J. Jensen, T. Hoeg-Jensen (eds.).听
European Peptide Society, 366-367, 2010.
M. Corbani, M. Trueba, S. Stoev, B. Murat, J. Mion, V. Boulay, G. Guillon and M. Manning
(2011)听.听 J. Med. Chem. 54:2864-2877.
M. Manning, A. Misicka, A. Olma, K. Bankowski, S. Stoev, B. Chini, T. Durroux, B.
Mouillac, M. Corbani and G. Guillon (2012)听听 J.听Neuroendocrinology 24:609-628.听听(Most highly cited J.N.E. publication in 2015)
M. Busnelli, E. Bulgheroni, M. Manning, G. Kleinau and B. Chini (2013)听听Journal听of听Pharmacology听and听Experimental Therapeutics.听 346:318-327.
M. Busnelli, G. Kleinau, M. Mutenthaler, S. Stoev, M. Manning, L. Bibic, L.A. Howell,
P.J. McCormick, S. Di Lascio, D. Braida, M. Sala, G.E. Rovati, T. Bellini and B. Chini
(2016)听. J. Med. Chem. 59:7152-7166.听 (ACS Editor's Choice of July 28, 2016)
M. Corbani, R. Marir, M. Trueba, M. Chafai, A. Vincent, A.M. Borie, M.J. Desarmenien,
Y. Ueta, C. Tomboly, A. Olma, M. Manning, G. Guillon (2018) Gen. Compar. Endocrinol. 258:15-32.
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