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Student-Faculty Publications

PUBLICATIONS

(bold = CCB student, faculty, staff, and alumni)Ìý

2024

Barlow L,ÌýJosephraj S, Gu B, Dong Z, Zhang JT. (2024) FASN negatively regulates the expression of p65 by diminishing its stability through phosphorylation at Thr254 and isomerization by Pin1. J Lipid Res. 65:100529.

Creeden JF, Sevier J, Zhang JT, Lapitsky Y, Brunicardi FC, Jin G, Nemunaitis J, Liu JY, Kalinoski A, Rao D, Liu SH. (2024) Smart exosomes enhance PDAC targeted therapy. J Control ReleaseÌý368:413-429.

Dreier MR, Walia J, de la Serna IL. (2024) Targeting SWI/SNF Complexes in Cancer: An Overview of Pharmacological Strategies and Consequences. Epigenomes. 2024 8:7.

Han D, Labaf M,ÌýZhao Y, Owiredu J, Zhang S, Patel K, Venkataramani K, Steinfeld JS, Han W, Li M, Liu M, Wang Z, Besschetnova A, Patalano S, Mulhearn MJ, Macoska JA, Yuan X, Balk SP, Nelson PS, Plymate SR, Gao S, Siegfried KR, Liu R, Stangis MM, Foxa G,ÌýCzernik PJ, Williams BO, Zarringhalam K,ÌýLi X, Cai C. (2024) Androgen receptor splice variants drive castration-resistant prostate cancer metastasis by activating distinct transcriptional programs.ÌýJ Clin Invest. 30:e168649.

Liu, R., Zhao, Y., Su, S., Kwabil, A., Njoku, P.C., Yu, H., Li, X.Ìý (2024) Unveiling cancer dormancy: Intrinsic mechanisms and extrinsic forces.ÌýCancer Lett. 591:216899.

Makinwa, Y., Luo, Y., Musich, P.R., Zou, Y. (2024) Canonical and noncanonical functions of the BH3 domain protein bid in apoptosis, oncogenesis, cancer therapeutics, and aging. Cancers 16:2199.

2023

Ahmad, N., de la Serna, I.L., Marathe, H.G., Fan, X., Dube, P., Zhang, S., Haller, S.T., Kennedy, D.J., Pestov, N.B., and Modyanov, N.N. (2023) Eutherian-specific functions of BetaM acquired through Atp1b4 gene co-option in the regulation of MyoD expression.

Argueta, C.E., Figy, C., Bouali, S., Guo, A., Yeung, K.C., Fenteany, G. (2023) RKIP localizes to the nucleus through a bipartite nuclear localization signal and interaction with importin α to regulate mitotic progression.Ìý J. Biol. Chem. 299:103023.Ìý

Basuroy, T., Dreier, M., Baum, C., Blomquist, T., Trumbly, R., Filipp, F.V., de la Serna, I.L. (2023) Epidgentic and pharmacological control of pigmentatin via Bromodomain Protein 9 (BRD9).ÌýPigment Cell Melanoma Res. 36:19-32.

Beamer, M.A., Zamora, C., Nestor-Kalinoski, A.L., Fernando, V., Sharma, V., and Furuta, S. (2023) Novel 3D flipwell system that models gut mucosal microenvironment for studying interactions between gut microbiota, epithelia and immunity. Sci .Rep. 13:870.

Biswas H, Makinwa Y, Zou Y. (2023) Novel cellular functions of ATR for therapeutic targeting:Ìý Embryogenesis to tumorigenesis. Int J Mol Sci. Jul20;24(14).

Cui, T, Huang, C, Liu J-Y and Zhang J-T (2023) Small molecule inhibitors targeting the "undruggable" survivin: The past, present, and future from a medicinal chemist's perspective. ÌýJ Med Chem 66(24): 16515-16545.

Figy, C.,ÌýGuo, A., Fernando, V.R., Furuta, S., Al-Mulla, F. , Yeung, K. (2023) Changes in expression of tumor suppressor gene RKIP impact how cancers interact with their complex environment. CancersÌý (Basel) 15:958. Ìý

Ghai, S., Young, A., and Su, K-H. (2023) Proteotoxic stress response in atherosclerotic cardiovascular disease: Emerging role of heat shock factor 1.Ìý Front. Cardiovasc. Med. 10:1155444,

Gurung, D., Danielson, J.A., Tasnim, A., Zhang, J.T., Zou, Y., Liu, J.Y. (2023) Proline isomerization: From the chemistry and biology to therapeutic opportunities. Biology (Basel) 12(7). doi:10.3390/biology12071008.37508437

Heck, H., Tipton, C. Becker, K., Creeden, J., Schroeder, J., Larder, C., Haak, P., Pyles, B., Eisenmann, K. (2023) Impact of COVID-19 on clinical productivity at the University of Toledo Medical Center Specialty Care Clinics. Translation The University of Toledo Journal of Medical Sciences, 11(2). doi:10.46570

Fernando, V., Zheng, X., Sharma, V., Furuta, S. (2023) Reprogramming of breast tumor-associated macrophages with modulation of arginine metabolism.ÌýPreprint. bioRxiv. 2023;2023.08.22.554238. Published 2023 Aug 22.

Letson, J., Furuta, S. (2023) Reduced S-nitrosylation of TGFβ1 elevates its binding affinity towards the receptor and promotes fibrogenic signaling in the breast. bioRxiv, 2023 Sep 12:2023.09.07.556714. doi:Ìýhttps://doi.org/10.1101/2023.09.07.556714

Qin, L., Dong, Z., Huang, C., Liu, H., Beebe, J., Subramaniyan, B., Hao, Y., Liu, Y., He, Z., Liu, J-Y., Zhang, J-T. (2023) Reversible promoter demethylation of PDGFD confers gemcitabine resistance through STAT3 activation and RRM1 upregulation. CÌý

Raman, D., Cimpean, A.M., and De Miglio, M.R. (2023) Editorial: Drug resistance in breast cancer - mechanisms and approaches to overcome chemoresistance. Front Oncol. 12:1080684.

Zajac, K.K., Malla, S., Babu, R.J.,ÌýRaman, D., Tiwari, A.K. (2023) ÌýEthnic disparities in the immune microenvironment of triple negative breast cancer and its role in therapeutic outcomes.ÌýCancer Rep (Hoboken). 2023:e1779.

2022

Alganem, K., Hamoud, A.R.,ÌýCreeden, J.F. , Henkel, N.D., Imami, A.S., et al. (2022) The active kinome: The modern view of how active protein kinase networks fit in biological research.Ìý Curr. Opin. Pharmacol. 62:117-129. doi: 10.1016/j.coph.2021.11.007

Bach, V.N., Ding, J., Yeung, M., Conrad, T., Odeh, H.N., Cubberly, P., Figy, C., Ding, H-F., Trumbly, R., and Yeung, K.C. (2022) A negative regulatory role for RKIP in breast cancer immune response. Cancers 14:3605. Ìý

Balaji, S., Neupane, R., Malla, S., Khupse, R., Amawi, H., Kumari, S., Tukaramrao, D.B., Chattopadhyay, S., Ashby, C.R., Jr., Boddu, S.H.S., Karthikeyan, C., Trivedi, P.,ÌýRaman, D., and Tiwari, A.K.Ìý(2022) IND-2, a Quinoline derivative, inhibits the proliferation of prostate cancer cells by inducing oxidative stress, apoptosis and inhibiting topoisomerase II.ÌýLife (Basel) 12(11).

Beebe, J., Josephraj, S., Wang, C.J., Danielson, J., Cui, Q., Huang, C.,ÌýBarlow, L., Zhang, R.H., Zhang, T., Nakshatri, H., Dong, Z., Li, X., Liu, JY., and Zhang, JT. (2022) Therapeutic activity of the lansoprazole metabolite 5-hydroxy lansoprazole sulfide in triple-negative breast cancer by inhibiting the enoyl reductase of fatty acid synthase. J. Med. Chem.,Ìý 65:13681-13691. Ìý

Becker, K.N., Gifford, C.S., Qaqish, H., Alexander, C., Ren, G., Caras, A., Miller, W.K., Schroeder, J.L. (2022) A population-based study of patients with sleep-wake disorders undergoing elective instrumented spinal surgery. World Neurosurg.,Ìý

Becker, K.N., Eisenmann, K. M. (2022) New targets in the glioblastoma tumor microtube multiverse: Emerging roles for the TGF-beta/TSP1 signaling axis. Neuro-Oncology,

Becker, K.N., Pettee, K.M., Sugrue, A., Reinard, K.A., Schroeder, J.L.,ÌýEisenmann, K.E.Ìý (2022) The cytoskeleton effectors Rho-kinase (ROCK) and mammalian diaphanous-related (mDia) formin have dynamic roles in tumor microtube formation in invasive glioblastoma cells. Cells 11:1159Ìý h

Biswas, H., Zhao, S., Makinwa, Y., Bassett, J.S., Pike, M., Musich, P.R., Liu, JY,Ìý Zou, Y. (2022) Prolyl isomerization-mediated conformational changes define ATR subcellular compartment-specific functions. Front . Cell Dev. Biol. , 10:826576.Ìý doi: 10.3389/fcell.2022.826576

Butt, E., Howard, C.M., and Raman, D. (2022) LASP1 in cellular signaling and gene expresson: More than just a cytoskeletal regulator. Cells 11:3817. doi: 10.3390/cells11233817

Creeden, J.F.,ÌýKipp, Z.A., Xu, M., Flight, R.M., Moseley, H.N.B., et al. (2022) Hepatic kinome atlas: An in-depth identification of kinase pathways in liver fibrosis of humans and rodents. Hepatol. 76:1376-1388.

Elke, B.,ÌýHoward,C.M.,ÌýandÌýRaman, D. (2022) LASP1 in cellular signaling and gene expression: More than just a cytoskeletal regulator. Cells 11:3817.Ìý

Peery, R., Cui, Q., Kyei-Baffour, K., Josephraj, S., Huang, C., Dong, Z., Dai, M., Zhang, J-T., Liu, J-Y. (2022) A novel survivin dimerization inhibitor without a labile hydrazone linker induces spontaneous apoptosis and synergizes with docetaxel in prostate cancer cells.

Sharma, V., Letson, J., Furuta, S. (2022) Fibrous stroma: Driver and passenger cancer development.Ìý Sci. Signal.Ìý15.

2021

Becker, K.N., Pettee, K.M., Sugrue, A,. Reinard, K.A., Schroeder, J.L., Eisenmann, K.M. (2021)Ìý.ÌýCancer Res. 81:2.

Craig, D.J., Crawford, E.L., Massion, P.P., Morrison, T.,ÌýWilley, J.C. (2021)ÌýCancer Res. 81:1.

Crawford, E.L., Chen T., Craig, D.J., Willey, J.C. (2021)Ìý.ÌýCancer Res. 81:2.

Creeden, J.F., Imami, A.S., Eby, H.M. Gillman, C., Becker, K.N., Reigle, J., Andari, E., Pan, Z.K., O'Donovan, S.M., McCullumsmith, R.E., and McCullumsmith, C.B. (2021) . Biomed. Pharmacother. 138:111437.

Gardiyawasam, K., Figy, C., Feng, J., Tipton, C., De Castro, J.N., Bach, V.N., Borile, C., LaSalla, A., Odeh, H.N., Yeung, M., Garcia-Mata, R., Yeung, K.C. (2021) The RhoA dependent anti-metastatic function of RKIP in breast cancer. Nature Sci. Rep. 11:17455.

Kalpana, G., Figy, C., Feng, J., Tipton, C., DeCastro, J.N., Bach, V.N., Borile, C., LaSalla, A., Odeh, H.N., Yeung, M., Garcia-Mata, Yeung, K.C. (2021)Ìý Nature Sci. Rep. 11:17455.

Li , Z., Hui Wang-Heaton, H., Cartwright, B.M., Makinwa, Y., Hilton, B.A., Musich, P.R., Shkriabai, N., Kvaratskhelia, M.K., Guan, S., Chen, Q., Yu, X., and Zou, Y. (2021)Ìý.ÌýFASEB JÌý 35(5):e21373.

O'Donovan, S.M., Imami, A., Eby, H., Henkel, N.D., Creeden, J.F., Asah, S., Zhang, X., Wu, X., Alnafisah, R., Taylor, R.T., Reigle, J., Thomran, A., Shamsaei, B., Meller, J., and McCullumsmith, R.E. (2021) . Scientific Reports, 11(1): 4495.

Ren, G., Zheng, X., Sharma, V., Letson, J., Nestor-Kalinoski, A.L., Furuta, S.Ìý(2021)Ìý.ÌýCancers. 13. 15

Sharma, V., Fernando, V., Letson, J., Walia, Y., Zheng, X., Fackelman, D., and Furuta, S. (2021) .Ìý Int. J. Mol. Sci. 22:(9).

2020

Craig, D.J., Creeden, J.F., Einloth, K.R., Gillman, C.E., Stanbery, L., Hamouda, D., Edelman, G., Dworkin, L., and Nemunaitis, J.J.Ìý (2020) .Ìý Vaccines (Basel)Ìý 8(4).

Creeden, J.F., Alganem, K., Imami, A.S., Henkel, N.D., Brunicardi, F.C., Liu, S-H., Shukla, R., Tomar, T., Naji F., and Mccullumsmith, R.E. (2020) . Int. J. Mol. Sci. 21(22).

Gurung, D., and Blumenthal, R.M. (2020) .Ìý Microbiology (Reading) 166(11).

Howard, C.M, Estrada, M., Terreo, D., Tiwari, A.K., and Raman, D. (2020) . Cancers 12(8).

Makinwa, Y., Cartwright, B.M., Musich, P.R., Li, Z., Biswas, H., and Zou, Y. (2020) ÌýFron. CellÌý Dev. Biol. 8:813

Makinwa, Y., Musich, P.R., and Zou, Y. (2020). Fron. Cell Dev. Biol. 8:281.

Liu, S-H., Yu, J.H., Creeden, J.F., Sutton, J.M., Markowiak, S., Sanchez, R., Nemunaitis, J., Kalinoski, A., and Zhang, J.T. (2020) . Cancer Lett., 491:97107.

Subramaniyan, B., Sridharan, S., Howard, C.M., Basuroy, T., de la Serna, I., Butt, E., and Raman, D. (2020) Cancers 12(9).

Tilley, A.M.C., Howard, C.M., Sridharan, S., Subramaniyan, B., Bearss, N.R., Alkhalili, S., and Raman, D. (2020) Cancers 12(9).

Trivedi, A., Mehrotra, A., Baum, C.E., Lewis, B., Basuroy, T., Blomquist, T., Trumbly, R., Filipp, F.V., Setaluri, V., andÌýde la Serna, I.L. Epigenetics Chromatin. (2020)Ìý 10;13(1):14. doi: 10.1186/s13072-020-00333-z.

Zheng, X., Fernando, V., Sharma, V., Walia, Y., Letson, J., Furuta, S. (2020) Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer. Biochem. Pharmacol. 113887. doi;10.1016/j.bcp.2020.113887.

Makinwa, Y., Cartwright, B.., Musich, P.R., Li, Z., and Zou, Y. (2020) . Front Cell Dev Biol. 8:281.

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