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University of Toledo Integrated Core Facilities (ICF)

Andrea L. Kalinoski, Ph.D.

Andrea Kalinoski, Ph.D. Associate Professor
Director Integrated Core Facilities
Office: 419.383.4205
贰尘补颈濒:听Andrea.Kalinoski@utoledo.edu

EDUCATION

B.A., Biology, University of Toledo, Toledo, Ohio 1994
Ph.D., Medical Sciences, Medical College of Ohio, Toledo, Ohio, 2003听

POSTGRADUATE TRAINING

  • University of Toledo Health Science Campus, Department of Surgery, Toledo, Ohio 2003-2009听

ACADEMIC APPOINTMENTS

  • 1994- 1998: Medical College of Ohio, Department of Surgery, Research Associate, Toledo, Ohio听
  • 2003- 2009: Post-Doc Fellow, Department of Surgery, Toledo Ohio, Toledo Ohio听
  • 2006- 2013: Technical Director, Advanced Microscopy & Imaging Center, Toledo Ohio, Toledo Ohio听
  • 2009- 2014: Assistant Professor, University of Toledo, Department of Surgery, Toledo, Ohio听
  • 2013- 2024: Technical Director, UT Integrated Core Facilities (Advanced Microscopy & Imaging Center, Flow Cytometry and Histology), University of Toledo, College of Medicine and Life Sciences
  • 2015- Present: Associate Professor with Tenure, University of Toledo, Department of Surgery, Toledo, Ohio听听
  • 2024- Present: Director, UT Integrated Core Facilities (Advanced Microscopy & Imaging Center, Flow Cytometry, Histology and Transmission Electron Microscopy), University of Toledo, College of Medicine and Life Sciences

RESEARCH FUNDING

  • SPARC OT2OD023859 Howard (PI) 10/15/2016-09/30/2019 NIH
    Role Kalinoski (CO-I) Anatomical-Functional Mapping of Enteric Neural Circuits
  • University Research Award and Fellowship Vestal (PI) 6/01/2018-05/31/2019听
    Role Kalinoski (CO-I) GBP-1 in Glioblastoma
  • R01CA169500 Liu (PI) 05/01/2014-04/30/2018 NIH
    Role Kalinoski (CO-I) Trip12 AAA-ATPase overexpression in Chromosomal Instability and Breast Cancer

RESEARCH INTEREST

  1. Understanding the molecular signaling mechanisms within the vascular wall that results in the injury response and formation of neointimal hyperplasia.
  2. Understanding the signaling mechanisms within the vascular wall that result in fibroelastic changes and lead to arterial stiffness and/or decreased vascular tone.听

INTEGRATED CORE FACILITIES

The University of Toledo Integrated Core Facilities acquire, maintain and support state-of-the-art equipment thatenables cutting-edge research to be performed by helping researchers economically and efficiently take advantage of innovative technology and collaborate with experts in the field.

PUBLICATIONS (SELECTED)

  1. Allison DC,听Nestor AL.听听(1999)听Evidence for a relatively random array of human chromosomes on the mitotic ring.听听J Cell Bio 145: 1-14.听
  2. Assadnia S, Rapp JP,听Nestor AL, Cerilli GJ, Webb TH, Kligman M, Allison DC.听听(1999) Strain differences in neointimal hyperplasia in the rat.听Circ Res 84: 1252-1257.听
  3. *Isaka T, *Nestor AL, Takada T, Allison DC.听听(2003) Chromosomal variations within aneuploid cancer lines.听听J Histochem Cytochem 51(10): 343-1353.听听(*equal authorship)
  4. Nestor AL, Cicila GT, Karol SE, Langenderfer KM, Hollopeter SL, Allison DC.听听(2006) Linkage analysis of neointimal hyperplasia and vascular wall changes following balloon angioplasty.听听Physiol Genomics 25: 286-93.听
  5. Nestor AL, Hollopeter SL, Matsui SI, Allison DC. (2007) A Model for Genetic Complementation Controlling the Chromosomal Abnormalities and Loss of Heterozygosity Formation in Cancer.听听Cytogenet Genome Res 116:235-247.听
  6. Nestor Kalinoski AL, Ramdath RS, Langenderfer KM, Sikanderkhel S, DeRaedt S, Welch M, Park JL, Pringle T, Joe B, Cicila GT and Allison DC.听听(2010) Neointimal Hyperplasia and Vasoreactivity are Controlled by Genetic Elements on Rat Chromosome 3. Hypertension 55(2):555-561.听
  7. Stewart K, Olorunto W, Fink B, Zelenock, G, Allison DC,听Nestor Kalinoski AL.听听(2010) Resuscitation with Ketones Improves Survival Over Lactated Ringers in a Rat Shock Model.听听JACS听211(3):S52-3, 2010.
  8. Bazeley PS, Nestor听Kalinoski AL, Ways JA, Liu ST, Ramdath RS, Matsui SI and Allison, DC.听听(2011) A Model for Random Genetic Damage Directing the Selection of Diploid or Aneuploid Tumors.听听Cell Proliferation 44: 212-223.听听PMID: 21535262
  9. Wyse MM, Lei J,听Nestor-Kalinoski AL, and Eisenmann KM.听听(2012)听听Dia-interacting protein (DIP) imposes migratory plasticity in mDia2-dependent breast cancer cells in three-dimensional matrices.听听PLOS One 7(9): e45085.听听PMID: 23024796.
  10. Gopalakrishnan K, Kumarasamy S, Abdual-Majeed S,听Kalinoski A, Morgan EE, Gohara AF, Nauli SM, Filipiak WE, Saunders TL and Joe B. (2012) Validation of a Blood Pressure Quantitative Trait Gene Using a Targeted Disruption Rat Model.听听Proc Natl Acad Sci U S A. 109(50):20555-9.听听PMID: 23185005.
  11. Wagner DE, Eisenmann K ,听Nestor-Kalinoski AL, Bhaduri, SB. (2012) A Novel Microwave Assisted Solution Combustion Synthesis (MASCS) to Produce Europium Doped Calcium Phosphate Nanowhiskers for Multifunctional Bioimaging Applications.听Acta Biomaterialia.听(9):8422-32.听听PMID:听听23764803.
  12. ,听,听,听,听,听,听,听,听. (2013)听听Development and Characterization of Nanostructured Mists with Potential for Actively Targeting Poorly Water-Soluble Compounds into the Lungs.听听听10:2625-39.听听PMID:听听23722411.
  13. Weaver, DA,听Nestor-Kalinoski AL, Craig K, Gorris, M, Parikh T, Mabry H, Allison DC.听听(2014) Correction of Sampling Errors Finds Increased mRNA Levels Possibly Compensating for Cancer Haplo-Insufficiency.听听Genes Chromosomes Cancer听听53(2):194-210听听听PMID:听听24327546.
  14. Pettee KM, Dvorak KM,听Nestor-Kalinoski ALand Kathryn M Eisenmann KM.听听(2014)听听An mDia2/ROCK Signaling Axis Regulates Invasive Egress from Epithelial Ovarian Cancer Spheroids.听听PLoS One.听2014;听9(2): e90371.听听PMID:听24587343.
  15. Morgan EE, Casabianca AB, Khouri S, and Nestor-Kalinoski, AL. (2014) In vivo Assessment of Arterial Stiffness in the Isoflurane Anesthetized Spontaneously Hypertensive Rat.听听Cardiovascular Ultrasound,听12:37.听PMID:听听25227282
  16. Arden JD, Lavik KI, Rubinic KA, Chiaia N, Khuder SA, Howard MJ,听Nestor-KalinoskiAL, Alberts AS, Eisenmann KM.听听(2015)听听听Mol Biol Cell. Nov;26(21):3704-18.听听PMID:听听26354425.
  17. McBeth L, Nwaneri AC, Grabnar M, Demeter J,听Nestor-Kalinoski A, Hinds TD Jr. (2016)听听听OncotargetMay 10;7(19):27313-24.听听doi: 10.18632/oncotarget.8430.听听PMID:听听27036026.
  18. Wu X, Ren G, Gunning WT 3rd, Weaver DA,听Kalinoski AL, Khuder SA, Huntley JF.听听(2016)听听FmvB:听A Francisella tularenisi Magnesium-Responsive Outer Membrane Protein that Plays a Role in Virulence.听听PLoS One听听Aug11:11(8):e0160977.听听doi:10.1371/journal.pone.0160977. PMID:听听27513341.
  19. Hinds TD, Jr., Burns KA,听听Hosick PA, McBeth,L,听听Nestor-Kalinoski, A, Drummond, HA,听听AlAmodi, AA Hankins, MW, Vanden Heuvel, JP and Stec, DE.听(2016)听听Biliverdin reductase A attenuates hepatic steatosis by inhibition of glycogen synthase kinase (GSK) 3尾 phosphorylation of serine 73 of peroxisome proliferator-activated receptor (PPAR) 伪.听听听Journal of Biological Chemistry听听291(48):25179-25191.听听PMID:听27738106
  20. Marino JS, Stechschulte L, Stec DE,听Nestor-Kalinoski A, Coleman S, Hinds Jr TD. (2016) Glucocorticoid Receptor 尾 Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of PPAR伪.听听Journal of Biological Chemistry 291(50):25776-25788.听听PMID:听听27784782
  21. Nestor-Kalinoski, A.L.(2016) Second Harmonic Generation and Multiphoton Excited Fluorescence Microscopy as a Phenotypic Tool in an Animal Model. Microscopy and Microanalysis, 22(Suppl 3), 1060鈥�1061. doi: 10.1017/S1431927616006140.听听
  22. Hinds, TD Jr., Hosick PA, Hankins MW,听Nestor-Kalinoski AL, Stec DE.听(2017) Mice with hyperbilirubinemia due to Gilbert鈥檚 syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPAR伪.听听Am J Physiol Endocrinol Metab 听Apr 1;312(4):E244-E252.听听doi:10.1152/ajpendo.00396.2016. PMID:听听28096081
  23. Wyse MM, Goicoechea S, Garcia-Mata R,听Nestor-Kalinoski ALand Eisenmann KM.听听(2017)听听mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions.听听Biochemical and Biophysical Research Communications Mar 4;484(2):255-261.听doi: 10.1016/j.bbrc.2017.01.087. PMID:听28115158
  24. Patel J, Ge L, Ahmed S, Ariyarantne M, Phuntumart V,听Kalinoski A, Morris PF (2017)听听Dual functioning of plant arginases provides a third route for putrescine synthesis.听听Plant Science Vol 262: 62-73.听听doi.org/10.1016/j.plantsci.2017.05.011.
  25. Morran MP, Al-Dieri AG,听Nestor鈥怟alinoski AL, Jordan RK, Gupta NK and McInerney MF.听听(2018) Insulin receptor based lymphocyte trafficking in the progression of type 1 diabetes.听听Journal of Biological Methods 5(1):e85. DOI:听听10.14440/jbm.2018.209
  26. Dvorak KM, Pettee KM, Rubinic-Minotti K, Su R,听Nestor-Kalinoski A, Eisenmann KM. (2018)听听听PLoS One听Mar 29;13(3):e0195278. doi:10.1371/journal.pone.0195278.听听PMID:听29596520
  27. Ren G, Zheng X, Bommarito M, Metzger S, Walia Y, Letson J, Schroering A, Kalinoski A, Weaver D, Figy C, Yeung K, Furuta S.听Sci Rep.听2019 Apr 30;9(1):6688.听doi: 10.1038/s41598-019-43239-x.听PubMed PMID: 31040372; PubMed Central PMCID: PMC6491486.
  28. Liu SH, Hong Y, Markowiak S, Sanchez R, Creeden J, Nemunaitis J, Kalinoski A, Willey J, Erhardt P, Lee J, van Dam M, Brunicardi FC.听Cancer Lett.听2019 Aug 10;457:10-19.听doi: 10.1016/j.canlet.2019.04.036.听Epub 2019 May 3.听PubMed PMID: 31059751.
  29. Stec DE, Gordon DM, Nestor-Kalinoski AL, Donald MC, Mitchell ZL, Creeden JF, Hinds TD Jr.听Biomolecules.听2020 Mar 2;10(3).听doi: 10.3390/biom10030387.听PubMed PMID: 32131495; PubMed Central PMCID: PMC7175174.
  30. Gordon DM, Neifer KL, Hamoud AA, Hawk CF, Nestor-Kalinoski AL, Miruzzi SA, Morran MP, Adeosun SO, Sarver JG, Erhardt PW, McCullumsmith RE, Stec DE, Hinds TD Jr.听J Biol Chem.听2020 Jul 17;295(29):9804-9822.听doi: 10.1074/jbc.RA120.013700.听Epub 2020 May 13.听PubMed PMID: 32404366; PubMed Central PMCID: PMC7380202.
  31. Liu SH, Yu J, Creeden JF, Sutton JM, Markowiak S, Sanchez R, Nemunaitis J, Kalinoski A, Zhang JT, Damoiseaux R, Erhardt P, Brunicardi FC.听Cancer Lett.听2020 Oct 28;491:97-107.听doi: 10.1016/j.canlet.2020.08.002.听Epub 2020 Aug 21.听PubMed PMID: 32829010; PubMed Central PMCID: PMC8766172.
  32. Pollard CA, Morran MP, Nestor-Kalinoski AL.听Physiol Genomics.听2020 Nov 1;52(11):549-557.听doi: 10.1152/physiolgenomics.00089.2020.听Epub 2020 Sep 29.听Review.听PubMed PMID: 32991251; PubMed Central PMCID: PMC7686876.
  33. Nandedkar-Kulkarni N, Esakov E, Gregg B, Atkinson MA, Rogers DG, Horner JD, Singer K, Lundy SK, Felton JL, Al-Huniti T, Kalinoski AN, Morran MP, Gupta NK, Bretz JD, Balaji S, Chen T, McInerney MF.听J Immunol.听2021 Apr 1;206(7):1443-1453.听doi: 10.4049/jimmunol.1900357.听Epub 2021 Mar 3.听PubMed PMID: 33658296; PubMed Central PMCID: PMC8142694.
  34. Ren G, Zheng X, Sharma V, Letson J, Nestor-Kalinoski AL, Furuta S.听Cancers (Basel).听2021 Jun 5;13(11).听doi: 10.3390/cancers13112815.听PubMed PMID: 34198735; PubMed Central PMCID: PMC8201212.
  35. Margiotta JF, Smith-Edwards KM, Nestor-Kalinoski A, Davis BM, Albers KM, Howard MJ.听Front Physiol.听2021;12:652714.听doi: 10.3389/fphys.2021.652714.听eCollection 2021.听PubMed PMID: 34408655; PubMed Central PMCID: PMC8365335.
  36. Morgan EE, Morran MP, Horen NG, Weaver DA, Nestor-Kalinoski AL.听Physiol Genomics.听2021 Dec 1;53(12):534-545.听doi: 10.1152/physiolgenomics.00038.2021.听Epub 2021 Nov 10.听PubMed PMID: 34755572; PubMed Central PMCID: PMC9275012.
  37. Nestor-Kalinoski A.L., Smith-Edwards K.M., Meerschaert K, Margiotta J.F., Rajwa B., Davis, B.M., Howard, M.J.听 (2021)听 Unique Neural Circuit Connectivity of Mouse Proximal, Middle and Distal Colon Defines Regional Colonic Motor Patterns. 听Cell Mol Gastroenterol Hepatol. 2022;13(1):309-337.e3. doi: 10.1016/j.jcmgh.2021.08.016. Epub 2021 Sep 9. PMID: 34509687.
  38. Buckley KH, Nestor-Kalinoski AL, Pizza FX.听Front Physiol.听2022;13:845504.听doi: 10.3389/fphys.2022.845504.听eCollection 2022.听PubMed PMID: 35492593; PubMed Central PMCID: PMC9040890.
  39. Buckley KH, Nestor-Kalinoski AL, Pizza FX.听Int J Mol Sci.听2022 Jun 24;23(13).听doi: 10.3390/ijms23137028.听PubMed PMID: 35806032; PubMed Central PMCID: PMC9267068.
  40. Beamer MA, Zamora C, Nestor-Kalinoski AL, Fernando V, Sharma V, Furuta S.听Sci Rep.听2023 Jan 17;13(1):870.听doi: 10.1038/s41598-023-28233-8.听PubMed PMID: 36650266; PubMed Central PMCID: PMC9845379.
  41. Sigdel I, Ofori-Kwafo A, Heizelman RJ 3rd, Nestor-Kalinoski A, Prabhakarpandian B, Tiwari AK, Tang Y.听Front Bioeng Biotechnol.听2023;11:1227119.听doi: 10.3389/fbioe.2023.1227119.听eCollection 2023.听PubMed PMID: 37840664; PubMed Central PMCID: PMC10569307.
  42. Collins SA, Stinson HE, Himes A, Nestor-Kalinoski A, Ninan I.听Sci Adv.听2023 Nov 10;9(45):eadg4800.听doi: 10.1126/sciadv.adg4800.听Epub 2023 Nov 10.听PubMed PMID: 37948526; PubMed Central PMCID: PMC10637752.
  43. Creeden JF, Sevier J, Zhang JT, Lapitsky Y, Brunicardi FC, Jin G, Nemunaitis J, Liu JY, Kalinoski A, Rao D, Liu SH.听J Control Release.听2024 Apr;368:413-429.听doi: 10.1016/j.jconrel.2024.02.037.听Epub 2024 Mar 7.听PubMed PMID: 38431093.