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Department of Physiology and Pharmacology

Jasenka Zubcevic, Ph.D.

Jasenka听Associate Professor

419.383.4258

Jasenka.Zubcevic@蘑菇视频.Edu

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Areas of expertise

Neural control of blood pressure, electrophysiology, rodent models of hypertension.

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Education and training

BSc in Pharmacology with Study in Industry, Department of Physiology and Pharmacology, Bristol Heart Institute, Faculty of Medical and Veterinary Sciences, University of Bristol, Bristol, United Kingdom (July 2003).

PHD in Physiology, Department of Physiology and Pharmacology, Bristol Heart Institute, Faculty of Medical and Veterinary Sciences, University of Bristol, Bristol, United Kingdom (July 2008).

Postdoctoral Fellow (2008- 2009) University of North Texas Department of Integrative Physiology

听Postdoctoral Fellow (2009-2010) University of Pennsylvania Department of Cell and Developmental Biology

听Postdoctoral Fellow (2010-2013) University of Florida Department of Physiology and Functional Genomics

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Appointments

Research Assistant Professor (2013-2014) University of Florida Department of Physiology and Functional Genomics

Assistant Professor (2014-2020) University of Florida Department of Physiological Sciences听

Associate Professor (2021-present) University of Toledo Department of Physiology and Pharmacology

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Honors and awards

Donald J Reiss Memorial Trainee Award
American Physiological Society Cardiovascular Diseases Section
2006

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New Investigator Travel
AwardAmerican Heart Association
2011

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Best Presentation
AwardAmerican Heart Association
2011

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Onsite Trainee Poster Award
High Blood Pressure Research Scientific Sessions
2013

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C.E. Cornelius Young Investigator Award
College of Veterinary Medicine, University of Florida
2019

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The American Physiological Society Distinction in Scholarship
American Journal of Physiology-Heart and Circulatory Physiology
2019

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Research Interests

The overarching research theme of our laboratory is neural control of blood pressure in health and cardiometabolic disease. We focus our investigation on efferent and afferent mechanisms of blood pressure regulation that involve interactions between the CNS, ANS, cardiovascular, immune and GI systems. Most recently, we became interested in neural host-microbiota interactions via the vagal afferents present in the GI tract, and how these may regulate blood pressure in hypertension that is associated with gut dysbiosis. Our lab utilizes numerous in vitro, ex vivo, in vivo, in situ, electrophysiologic, imaging and multiple omics and bioinformatics approaches to answer research questions in several models of human cardiometabolic conditions including transgenic and humanized animals.

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Lab Members听

听Elliott DirrDr. Elliott Dirr

听Postdoctoral Fellow

听elliott.dirr@utoledo.edu

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Publications

  1. Gut-Liver Axis. Golonka RM, Cooper JK, Issa R, Devarasetty PP, Gokula V, Busken J,听Zubcevic J, Hill J, Vijay-Kumar M, Menon B, Joe B. Curr Hypertens Rep. 2021 May 7;23(5):28. doi: 10.1007/s11906-021-01142-9.听
  2. Tumor Necrosis Factor Alpha and the Gastrointestinal Epithelium: Implications for the Gut-Brain Axis and Hypertension. Souders CL 2nd,听Zubcevic J, Martyniuk CJ. Cell Mol Neurobiol. 2021 Feb 16. doi: 10.1007/s10571-021-01044-z. Online ahead of print.
  3. Ghrelin signaling regulates feeding behavior, metabolism, and memory through the vagus nerve. Davis EA, Wald HS, Suarez, AN, Zubcevic, J, Liu CM, Cortella AM, Kamitakahara AK, Polson JW, Arnold M, Grill HJ, de Lartigue G, Kanoski SE. Curr Biol. 2020 Sep 10:S0960-9822(20)31259-8. doi: 10.1016/j.cub.2020.08.069. Online ahead of print.
  4. The importance of bone marrow and the immune system in driving increases in blood pressure and sympathetic nerve activity in hypertension. Ahmari N, Hayward LF, Zubcevic J. Experimental Physiology, 10 September 2020听[in press.]
  5. Pulmonary arterial hypertension-associated changes in gut pathology and microbiota. Sharma RK, Oliveira AC, Yang T, Kim S, Zubcevic J, Aquino V, Lobaton GO, Goel R, Richards EM, Raizada MK. ERJ Open Res. 2020 Jul 27;6(3):00253-2019. doi: 10.1183/23120541.00253-2019. eCollection 2020 Jul.
  6. Gastrointestinal dysbiosis following diethylhexyl phthalate exposure in zebrafish (Danio rerio): altered microbial diversity, functionality, and network connectivity. Buerger AN, Dillon DT, Schmidt J, Yang T, Zubcevic J, Martyniuk CJ, Bisesi Jr JH. Environ Pollut. 2020 Oct;265(Pt B):114496. doi: 10.1016/j.envpol.2020.114496. Epub 2020 Apr 3.
  7. Martyniuk CJ, Mart铆nez R, Kostyniuk DJ, Mennigen JA,听Zubcevic J. Physiol Genomics. 2020 Apr 1;52(4):169-177. doi: 10.1152/physiolgenomics.00001.2020. Epub 2020 Feb 24.
  8. Donertas Ayaz B,听Zubcevic J. Pharmacol Res. 2020 Mar;153:104677. [doi: 10.1016/j.phrs.2020.104677]. Epub 2020 Feb 2.
  9. Kuan SP, Liao YJ, Davis KM, Messer JG,听Zubcevic J, Aguirre JI, Reznikov LR. iScience. 2019 Sep 27;19:737-748.[doi: 10.1016/j.isci.2019.08.011]. Epub 2019 Aug 8.
  10. Ahmari N, Santisteban MM, Miller DR, Geis NM, Larkin R, Redler T, Denson H, Khoshbouei H, Baekey DM, Raizada MK,听Zubcevic J. Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H279-H289.
  11. Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension: A Premise for Hypertension Therapy. Zubcevic J, Richards EM, Yang T, Kim S, Sumners C, Pepine CJ, Raizada MK. Circ Res. 2019 Jun 21;125(1):104-116. doi: 10.1161/CIRCRESAHA.119.313965. Epub 2019 Jun 20. Review.
  12. Yang T, Aquino V, Lobaton GO, Li H, Colon-Perez L, Goel R, Qi Y,听Zubcevic J, Febo M, Richards EM, Pepine CJ, Raizada MK. J Am Heart Assoc. 2019 Feb 19;8(4):e010721. doi: 10.1161/JAHA.118.010721.
  13. Yang T, Magee KL, Colon-Perez LM, Larkin R, Liao YS, Balazic E, Cowart JR, Arocha R, Redler T, Febo M, Vickroy T, Martyniuk CJ, Reznikov LR,听Zubcevic J. Acta Physiol (Oxf). 2019 Jan 18:e13256. doi: 10.1111/apha.13256. [Epub ahead of print]
  14. Jiron JM, Mendieta Calle JL, Castillo EJ, Abraham AM, Messer JG, Malphurs WL, Malinowski C, Grove K, Reznikov LR,听Zubcevic J, Aguirre JI. J Am Assoc Lab Anim Sci. 2019 Jan 1;58(1):40-49. doi: 10.30802/AALAS-JAALAS-18-000032. Epub 2018 Dec 20.
  15. Bartley A, Yang T, Arocha R, Malphurs WL, Larkin R, Magee KL, Vickroy TW,听Zubcevic J. Front Physiol. 2018 Nov 13;9:1593. doi: 10.3389/fphys.2018.01593. eCollection 2018.
  16. Yang T, Rodriguez V, Malphurs WL, Schmidt JT, Ahmari N, Sumners C, Martyniuk CJ,听Zubcevic J. Physiol Rep. 2018 Jul;6(14):e13732. doi: 10.14814/phy2.13732.
  17. Sharma RK, Oliveira AC, Kim S, Rigatto K,听Zubcevic J, Rathinasabapathy A, Kumar A, Lebowitz JJ, Khoshbouei H, Lobaton G, Aquino V, Richards EM, Katovich MJ, Shenoy V, Raizada MK. Hypertension. 2018 Jun;71(6):1156-1163. doi: 10.1161/HYPERTENSIONAHA.118.10934. Epub 2018 Apr 30.
  18. Zubcevic J, Watkins J, Perez PD, Colon-Perez LM, Long MT, Febo M, Hayward L. Brain Imaging Behav. 2018 Oct;12(5):1318-1331. doi: 10.1007/s11682-017-9798-4.
  19. Yang T,听Zubcevic J. Front Physiol. 2017 Oct 25;8:845. doi: 10.3389/fphys.2017.00845. eCollection 2017. Review.
  20. Zubcevic J, Santisteban MM, Perez PD, Arocha R, Hiller H, Malphurs WL, Colon-Perez LM, Sharma RK, de Kloet A, Krause EG, Febo M, Raizada MK. Front Physiol. 2017 Aug 31;8:592. doi: 10.3389/fphys.2017.00592. eCollection 2017.
  21. Zubcevic J, Baker A, Martyniuk CJ. Physiol Genomics. 2017 Jul 1;49(7):327-338. doi: 10.1152/physiolgenomics.00010.2017. Epub 2017 May 26. Review.
  22. Yang T, Ahmari N, Schmidt JT, Redler T, Arocha R, Pacholec K, Magee KL, Malphurs W, Owen JL, Krane GA, Li E, Wang GP, Vickroy TW, Raizada MK, Martyniuk CJ,听Zubcevic J. Front Physiol. 2017 Apr 12;8:220. doi: 10.3389/fphys.2017.00220. eCollection 2017.
  23. Perez PD, Hall G,听Zubcevic J, Febo M. Brain Imaging Behav. 2018 Feb;12(1):201-216. doi: 10.1007/s11682-017-9691-1.
  24. Santisteban MM, Qi Y,听Zubcevic J, Kim S, Yang T, Shenoy V, Cole-Jeffrey CT, Lobaton GO, Stewart DC, Rubiano A, Simmons CS, Garcia-Pereira F, Johnson RD, Pepine CJ, Raizada MK. Circ Res. 2017 Jan 20;120(2):312-323. doi: 10.1161/CIRCRESAHA.116.309006. Epub 2016 Oct 31.
  25. Ahmari N, Schmidt JT, Krane GA, Malphurs W, Cunningham BE, Owen JL, Martyniuk CJ,听Zubcevic J. Physiol Genomics. 2016 Jul 1;48(7):526-36. doi: 10.1152/physiolgenomics.00039.2016. Epub 2016 May 27.
  26. Santisteban MM, Ahmari N, Carvajal JM, Zingler MB, Qi Y, Kim S, Joseph J, Garcia-Pereira F, Johnson RD, Shenoy V, Raizada MK,听Zubcevic J. Circ Res. 2015 Jul 3;117(2):178-91. doi: 10.1161/CIRCRESAHA.117.305853. Epub 2015 May 11.
  27. Yang T, Santisteban MM, Rodriguez V, Li E, Ahmari N, Carvajal JM, Zadeh M, Gong M, Qi Y,听Zubcevic J, Sahay B, Pepine CJ, Raizada MK, Mohamadzadeh M. Hypertension. 2015 Jun;65(6):1331-40. doi: 10.1161/HYPERTENSIONAHA.115.05315. Epub 2015 Apr 13.
  28. Zubcevic J, Santisteban MM, Pitts T, Baekey DM, Perez PD, Bolser DC, Febo M, Raizada MK. Hypertension. 2014 Jun;63(6):e129-39. doi: 10.1161/HYPERTENSIONAHA.114.02440. Epub 2014 Mar 31. Review.听听
  29. Zubcevic J, Jun JY, Kim S, Perez PD, Afzal A, Shan Z, Li W, Santisteban MM, Yuan W, Febo M, Mocco J, Feng Y, Scott E, Baekey DM, Raizada MK. Hypertension. 2014 Mar;63(3):542-50. doi: 10.1161/HYPERTENSIONAHA.113.02722. Epub 2013 Dec 23.
  30. Santisteban MM,听Zubcevic J, Baekey DM, Raizada MK. Curr Hypertens Rep. 2013 Aug;15(4):377-89. doi: 10.1007/s11906-013-0361-4. Review.
  31. Shan Z,听Zubcevic J, Shi P, Jun JY, Dong Y, Mur莽a TM, Lamont GJ, Cuadra A, Yuan W, Qi Y, Li Q, Paton JF, Katovich MJ, Sumners C, Raizada MK. Hypertension. 2013 Jun;61(6):1328-33. doi: 10.1161/HYPERTENSIONAHA.111.00156. Epub 2013 Apr 1.
  32. de Kloet AD, Krause EG, Shi PD,听Zubcevic J, Raizada MK, Sumners C. Pharmacol Ther. 2013 Jun;138(3):428-40. doi: 10.1016/j.pharmthera.2013.02.005. Epub 2013 Feb 28. Review.
  33. Zubcevic J, Jun JY, Lamont G, Mur莽a TM, Shi P, Yuan W, Lin F, Carvajal JM, Li Q, Sumners C, Raizada MK, Shan Z. Hypertension. 2013 Mar;61(3):622-7. doi: 10.1161/HYPERTENSIONAHA.111.199836. Epub 2013 Jan 14.
  34. Jun JY,听Zubcevic J, Qi Y, Afzal A, Carvajal JM, Thinschmidt JS, Grant MB, Mocco J, Raizada MK. Hypertension. 2012 Nov;60(5):1316-23. doi: 10.1161/HYPERTENSIONAHA.112.199547. Epub 2012 Oct 8.
  35. Zubcevic J, Waki H, Raizada MK, Paton JF. Hypertension. 2011 Jun;57(6):1026-33. doi: 10.1161/HYPERTENSIONAHA.111.169748. Epub 2011 May 2. Review.
  36. Zubcevic J, Potts JT. Exp Physiol. 2010 Sep;95(9):909-18. doi: 10.1113/expphysiol.2010.054007. Epub 2010 Jun 30.
  37. Sun C,听Zubcevic J, Polson JW, Potts JT, Diez-Freire C, Zhang Q, Paton JF, Raizada MK. Circ Res. 2009 Dec 4;105(12):1248-55. doi: 10.1161/CIRCRESAHA.109.208926. Epub 2009 Oct 22.
  38. Zubcevic J, Waki H, Diez-Freire C, Gampel A, Raizada MK, Paton JF. Hypertension. 2009 Jan;53(1):97-103. doi: 10.1161/HYPERTENSIONAHA.108.122341. Epub 2008 Nov 17.
  39. Huentelman MJ,听Zubcevic J, Hern谩ndez Prada JA, Xiao X, Dimitrov DS, Raizada MK, Ostrov DA. Hypertension. 2004 Dec;44(6):903-6. Epub 2004 Oct 18.
  40. Huentelman MJ,听Zubcevic J, Katovich MJ, Raizada MK. Regul Pept. 2004 Oct 15;122(2):61-7.

Press

Zubcevic J and Martyniuk CM. The Washington Post, Aug 13th, 2017.听

Zubcevic J and Martyniuk CM. The Observer, July 10th, 2017.